These characteristics may be helpful in distinguishing acute symptomology due to CHF, COPD or asthma.P310 Determination of expiratory lung Vorapaxar Purity & Documentation mechanics using cardiogenic oscillations during decelerated expirationA Wahl1, M Lichtwarck-Aschoff2, K M ler3, S Schumann1, J Guttmann1 1Vorapaxar site University Hospital Freiburg, Germany; 2Uppsala University, Sweden; 3Furtwangen University, Furtwangen, Germany Critical Care 2008, 12(Suppl 2):P310 (doi: 10.1186/cc6531) Introduction Mechanical energy from the beating heart is transferred to the lung, inducing variations in the airway pressure signal called cardiogenic oscillations (COS), which we hypothesize reflect intratidal nonlinear lung mechanics. Bijaoui E, et al.: J Appl Physiol 2001, 91:859-865.Figure 1 (abstract P310)P309 Lung sound patterns of exacerbation of congestive heart failure, chronic obstructive ML329 Data Sheet pulmonary disease and asthmaT Bartter, Z Wang Cooper University Hospital, Camden, NJ, USA Critical Care 2008, 12(Suppl 2):P309 (doi: 10.1186/cc6530) Introduction Congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and asthma patients typically present with abnormal auscultatory G1T28 Inhibitor findings on lung examination. These characteristics may be helpful in distinguishing acute symptomology due to CHF, COPD or asthma.P310 Determination of expiratory lung mechanics using cardiogenic oscillations during decelerated expirationA Wahl1, M Lichtwarck-Aschoff2, K M ler3, S Schumann1, J Guttmann1 1University Hospital Freiburg, Germany; 2Uppsala University, Sweden; 3Furtwangen University, Furtwangen, Germany Critical Care 2008, 12(Suppl 2):P310 (doi: 10.1186/cc6531) Introduction Mechanical energy from the beating heart is transferred to the lung, inducing variations in the airway pressure signal called cardiogenic oscillations (COS), which we hypothesize reflect intratidal nonlinear lung mechanics. However, during high flow rate, as characteristic for passive expiration, the analysis of lung mechanics is impractical since COS are almost suppressed and the quantity is low. Methods Five piglets with atelectasis were investigated during constant inspiratory flow mechanical ventilation with positive endexpiratory pressure of 0, 5, 8, 12 and 16 mbar. The airflow rate, airway pressure, pleural pressure and ECG were recorded (sample frequency 100 Hz). The expiratory airflow rate was limited using two switchable tubes of different lumen. Signals were separated and compared by each breath. Results Compared with passive expiration COS in decelerated expiration became clearly distinguishable (Figure 1). COS amplitudes were increasing with decreasing airflow rate. Conclusions By decelerating the expiration, COS become distinguishable and therefore analyzable. With this method, lung mechanics can be determined separately in expiration. References 1. Lichtwarck-Aschoff M, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/7895057 et al.: J Appl Physiol 2004, 96:879-884. 2. Bijaoui E, et al.: Adv Exp Med Biol 2004, 551:251-257. 3. Bijaoui E, et al.: J Appl Physiol 2001, 91:859-865.Figure 1 (abstract P310)P309 Lung sound patterns of exacerbation of congestive heart failure, chronic obstructive pulmonary disease and asthmaT Bartter, Z Wang Cooper University Hospital, Camden, NJ, USA Critical Care 2008, 12(Suppl 2):P309 (doi: 10.1186/cc6530) Introduction Congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and asthma patients typically present with abnormal auscultatory findings on lung examination. The aim of this study was to evaluate in detail the distribution of respiratory sound intensity in CHF, COPD and asthma patients during acute exacerbation. Methods Respiratory sounds throughout the respiratory cycle were captured and displayed using an acoustic-based imaging technique.