Acknowledgments: We would prefer to acknowledge William Russell Title Loaded From File Director in the UTMB Proteomics Core (the UTMB Mass Spectrometry Facility is supported in part by CPRIT grant no. Iranian Journal of Pharmaceutical Research (2021), 20 (3): 381-398 DOI: 10.22037/ijpr.2021.114785.15032 Received: December 2020 Accepted: FebruaryOriginal ArticleSelf-emulsifying Drug Delivery System for Enhanced Dissolution and Oral Absorption of Quetiapine Fumarate: Investigation of Drug Release Mechanism and In-vitro Intestinal Title Loaded From File PermeabilityOlfa Ben Hadj Ayed , Mohamed Ali Lassoued, Badr Bahloul and Souad SfarLaboratory of Pharmaceutical, Chemical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia. We would also prefer to give specific because of the NSRL Physicists, Michael Sivertz, Chiara La Tessa, I-Hung Chiang, and Adam Rusek; the NSRL Support, Angela Kim, Paula Bennett, James Jardine, Leah Selva, and Peter Guida; the BLAF Group: Debbie Snyder, Kerry Bonti, Corinne Baran, and MaryAnn Petry; and other individuals at the BNL, for HZE beamline access and help with animal care and irradiations. Conflicts of Interest: The authors have no conflict of interest to declare.
Iranian Journal of Pharmaceutical Investigation (2021), 20 (3): 381-398 DOI: 10.22037/ijpr.2021.114785.15032 Received: December 2020 Accepted: FebruaryOriginal ArticleSelf-emulsifying Drug Delivery Technique for Improved Dissolution and Oral Absorption of Quetiapine Fumarate: Investigation of Drug Release Mechanism and In-vitro Intestinal PermeabilityOlfa Ben Hadj Ayed , Mohamed Ali Lassoued, Badr Bahloul and Souad SfarLaboratory of Pharmaceutical, Chemical and Pharmacological Drug Improvement LR12ES09, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia. Abstract In this study, we focused on quetiapine fumarate (QTF), a class II BCS drug. QTF is definitely an atypical antipsychotic employed in the treatment of schizophrenia and bipolar issues. Our objective was to develop a new QTF-loaded self-emulsifying drug delivery method (SEDDS) to improve the dissolution and absorption with the drug. An experimental design and style strategy was made use of to develop and optimize QTF-loaded SEDDS. The optimized formulation was characterized for droplets size, zeta possible, PDI, and stability. It was then evaluated employing an in-vitro combined test for dissolution and Everted gut sac approach. Mathematical modeling and Transmission electron microscopy (TEM) were utilised to elucidate the mechanism of release. The optimal formulation was sort IIIB SEDDS, constituted of 9.1 of oleic acid, 51.six of Tween0, and 39.three of TranscutolP. It showed a droplets size of 144.eight four.9nm with an acceptable PDI and zeta potential. For in-vitro evaluation tests, we noticed an enhancement on the dissolution rate of the optimal QTF-loaded SEDDS when compared with the no cost drug (98.82 1.24 for SEDDS following 30 min when compared with 85.65 two.5 for the pure drug). The release of QTF fitted with the Hopfenberg model indicating the drug was released by water diffusion and erosion mechanism. This outcome was confirmed by TEM images which showed a smaller sized droplet size soon after release. We also found an amelioration from the permeability of QTF of 1.69-fold from SEDDS in comparison to the no cost drug. Hence, the SEDDS formulation represented a brand new approach to increase the dissolution and absorption of QTF. Ke.