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发布于:2023-5-27 05:35:09  访问:54 次 回复:0 篇
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Iz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible
Krishnan J, Danzer C, Simka T, Ukropec J, Walter KM, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, 3,4-Dimethoxy-3-cyclobutene-1,2-dione Autophagy Pedrazzini T, Krek W. Nutritional obesity-associated 2,tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate Inhibitor 6-Dibromopyrazine Purity Hif1alpha activation in adipocytes restricts fatty acid oxidation and electrical power expenditure by way of suppression in the Sirt2-NAD+ program. Tobita T, Guzman-Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, Deng CX, Collin DLA, Soto-Gutierrez A. SIRT1 disruption in human fetal hepatocytes results in enhanced accumulation of glucose and lipids. PLoS One. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25626861 2016;eleven:e149344. 49. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado DOR, Leid M, McBurney MW, Guarente L. Sirt1 encourages extra fat mobilization in white adipocytes by repressing PPAR-gamma. Mother nature. 2004;429:771?. fifty. Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocytespecific deletion of SIRT1 alters fatty acid metabolism and benefits in hepatic steatosis and inflammation. Mobile Metab. 2009;nine:327?eight.Mei et al. Journal of Experimental Clinical Most cancers Exploration (2016) 35:Web site 12 of51. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic regulate of muscle mass mitochondrial operate and fatty acid oxidation via SIRT1/PGC-1alpha. EMBO J. 2007;26:1913?three. 52. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates vitality expenditure by modulating NAD+ fat burning capacity and SIRT1 action. Mother nature. 2009;458:1056?0. 53. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation on the acetylation status, cytosolic localization, and exercise of LKB1. Doable position in AMPactivated protein kinase activation. J Biol Chem. 2008;283:27628?5. fifty four. Mariani S, Fiore D, Persichetti A, Basciani S, Lubrano C, Poggiogalle E, Genco A, Donini LM, Gnessi L. Circulating SIRT1 raises immediately after intragastric balloon fat loss in obese individuals. Obes Surg. 2016;26:1215?0. fifty five. Mariani S, Fiore D, Basciani S, Persichetti A, Contini S, Lubrano C, Salvatori L, Lenzi A, Gnessi L. Plasma amounts of SIRT1 affiliate with non-alcoholic fatty liver illness in obese sufferers. Endocrine. 2015;forty nine:711?. fifty six. Mariani S, Costantini D, Lubrano C, Basciani S, Caldaroni C, Barbaro G, Poggiogalle E, Donini LM, Lenzi A, Gnessi L. Circulating SIRT1 inversely correlates with epicardial body fat thickness in sufferers with being overweight. Nutr Metab Cardiovasc Dis. 2016;26:1033?. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28454499 57. Wang F, Tong Q. SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and boosting FOXO1‘s repressive interaction with PPARgamma. Mol Biol Cell. 2009;twenty:801?. 58. Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013;fifty one:506?eight. fifty nine. Krishnan J, Danzer C, Simka T, Ukropec J, Walter KM, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, Pedrazzini T, Krek W. Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and electricity expenditure by means of suppression of your Sirt2-NAD+ system. Genes Dev.
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