The epitopes qualified from the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally produced on a 10201-71-5 Data Sheet variety of web-sites of (533-30-2 Technical Information professional)filaggrin by deimination of arginine residues. Vossenaar ER, Despr N, Lapointe E, van der Heijden A, Lora M, Senshu T, et al. Rheumatoid arthritis precise anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther. 2004;6:R142?0. ten. Burkhardt H, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/1951575 Sehnert B, Bockermann R, Engstr A, Kalden JR, Holmdahl R. Humoral immune response to citrullinated collagen sort II determinants in early rheumatoid arthritis. Eur J Immunol. 2005;35:1643?2. eleven. Kinloch A, Tatzer V, Wait around R, Peston D, Lundberg K, Donatien P, et al. Identification of citrullinated alpha-enolase as a prospect autoantigen in rheumatoid arthritis. Arthritis Res Ther. 2005;seven:R1421?. 12. Pratesi F, Dioni I, Tommasi C, Alcaro MC, Paolini I, Barbetti F, et al. Antibodies from people with rheumatoid arthritis target citrullinated histone four contained in neutrophils extracellular traps. Ann Rheum Dis. 2014;seventy three:1414?two. 13. Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GMC, van Veelen PA, et al. Autoantibodies recognizing carbamylated proteins are present in sera of clients with rheumatoid arthritis and predict joint destruction. Proc Natl Acad Sci Usa. 2011;108:17372?. fourteen. Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, H kk?S, Barnard J, et al. Protein carbamylation one-way links inflammation, cigarette smoking, uremia and atherogenesis. Nat Med. 2007;13:1176?four. fifteen.Thology, 151103-08-1 Purity ��723% Uppsala University, Uppsala, Sweden. Received: 16 February 2016 Accepted: 22 AprilReferences one. Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, et al. The epitopes specific via the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally produced on several internet sites of (professional)filaggrin by deimination of arginine residues. J Immunol. 1999;162:585?4. 2. Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification conditions. Rheumatology (Oxford). 2012;51 Suppl six:vi5?. three. Klareskog L, Stolt P, Lundberg K, K lberg H, Bengtsson C, Grunewald J, et al. A brand new product for an etiology of rheumatoid arthritis: using tobacco could result in HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;fifty four:38?6. 4. Huizinga TWJ, Amos CI, van der Helm-van Mil AHM, Chen W, van Gaalen FA, Jawaheer D, et al. Refining the elaborate rheumatoid arthritis phenotype based on specificity of your HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 2005;fifty two:3433?. 5. K lberg H, Padyukov L, Plenge RM, R nelid J, Gregersen PK, van der Helm-van Mil AHM, et al. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking cigarettes in two subsets of rheumatoid arthritis. Am J Hum Genet. 2007;eighty:867?5. six. Linn-Rasker SP, van der Helm-van Mil AHM, van Gaalen FA, Kloppenburg M, de Vries RRP, le Cessie S, et al. Smoking is often a hazard element for anti-CCP antibodies only in rheumatoid arthritis people who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis. 2006;sixty five:366?1. 7.