The alter in physique weight didn‘t Title Loaded From File correlate with Title Loaded From File either the dose (p = 0.818), or with the duration of danazol treatment. Our findings indicate that long-term Title Loaded From File treatment together with the lowest successful dose of danazol has only a mild virilizing impact, since the individuals experienced 3 on average out of the 12 monitored adverse events. The alter in physique weight did not correlate with either the dose (p = 0.818), or with the duration of danazol remedy. Menstrual disturbances occurred in 8 individuals. Six of those individuals discontinued danazol (mainly because they wanted to have a child) and their menstrual cycles became typical once again. The mean score (VAS, 100 mm per scale) of patient satisfaction was 84 (min.: 30, max.: one hundred). None on the individuals discontinued danazol therapy as a consequence of virilizing adverse events. The Pearson‘s test did not detect any significant correlation involving patient satisfaction with danazol as well as the duration of therapy, or the each day drug dose. Comparing female HAE individuals with their age-matched, healthful controls, we didn‘t detect a statistically significant difference inside the majority in the study parameters. Water retention and psychological abnormalities were exceptions, as their incidence was statistically larger in the control group than amongst the patients (29 vs. six , p = 0.0177; and 46 vs. 16 , p = 0.011, respectively). Our findings indicate that long-term therapy using the lowest helpful dose of danazol has only a mild virilizing effect, due to the fact the individuals seasoned 3 on average out with the 12 monitored adverse events. The severity of the virilizing adverse effects (scored in the variety from 0 to 3) was beneath 0.five in all instances, plus the overall score was as low as 0.7 for the entire study population. Of note, the mean age of our patients was in the age variety when menopause usually occurs therefore, these adverse effects might even have resulted from spontaneous proandrogenic events. In agreement with literature information, by far the most popular adverse effects incorporated hirsutism, weight gain, and menstrual disturbances (Table 1). Weight obtain has not however been demonstrated to become a direct consequence of treatment with AAs, though we identified that the longer the duration of remedy, the larger the physique mass index with the female patients. Even so, the magnitude in the change in physique weight didn‘t correlate with any from the above parameters. Hirsutism occurred additional usually than in the other studies, but its frequency didn‘t exceed that observed within the Hungarian common population, as well as it was of mild severity. Menstruation disturbances werecommon but reversible and resolved right after AAs had been discontinued; that is also in agreement using the observations published inside the literature. Several authors emphasized that these adverse effects are dose-related [14,18,19]. We couldn‘t demonstrate this relationship in our study, mainly because our sufferers have been taking relatively low doses. Nonetheless, this observation further supports the practice of administering the lowest helpful dose to prevent unwanted side effects. Discontinuing prophylactic treatment because of the virilizing impact of danazol was not necessary in any of our patients.