Moreover, the stretching vibration peaks with the Title Loaded From File carbonyl group CO ar nificantly distinct. Fourier Transform InfraRed FTIR Spectrophotometric AnalysisFrom the FTIR spectrum Figure 13, it might be observed that AZI has an O vibrational region at 3400 cm1, a peak at 3494 cm1 indicating the presence o bound water, and also a peak at 3560 cm1, indicating the presence of two crystallin AZI 27,28, though the polymer does not have a stretching vibrational peak in th Meanwhile, for AZIRL PO, the O stretching vibration peak 3560 cm1 dis and only a broad absorption peak 3419 cm1, indicating the loss of AZI cry for the duration of the HME process along with the formation of loosely bound water 27.Ared. Combined with all the DSC spectrum results Figure 8, it was concluded that the AZI in the extrudate was dispersed in EudragitRL PO in an amorphous state, and formed a strong remedy. three.3.three. Fourier Transform InfraRed FTIR Spectrophotometric AnalysisFigure 11. DSC thermal curve AZIRL PO a EudragitRL PO b PM c AZI d.In the FTIR spectrum Figure 13, it may be observed that AZI has an O stretching Figure 11. DSC thermal curve AZIRL PO a EudragitRL PO b PM c AZI vibrational region at 3400 cm1 , a peak at 3494 cm1 indicating the presence of tightly bound water, as well as a peak at 3560 cm1 , indicating the presence of two crystalline water in AZI 27,28, though the polymer will not possess a stretching vibrational peak in this region. Meanwhile, for AZIRL PO, the O stretching vibration peak 3560 cm1 disappeared and only a broad absorption peak 3419 cm1 , indicating the loss of AZI crystal water for the duration of the HME course of action as well as the formation of loosely bound water 27. This shows aPolymers 2022, 14,the pure AZI, indicating that it can be a crystalline structure the polymer of Eudrag appeared in an amorphous state PM peaks correspond to pure crystalline AZI, of your peaks became weaker andPO a PM b Eudragit eaks of AZIRL PO dis Figure 12. PXRD spectrum AZIRL the crystal diffraction RL PO c AZI d. Combined with the DSC spectrum benefits Figure 8, it was concludedofthat the 12 15 RL PO in an amorphous state, and type extrudate wasTransform InfraRed FTIR Spectrophotometric Evaluation three.three.3. Fourier dispersed in Eudragit answer. From hydrogen bond interaction among 13, it Eudragit seen that AZI has an feasible the FTIR spectrum Figure AZI and can be RL PO in strong dispersion O ready by HME. vibrational area at 3400 cm1, a peak at 3494 cm1 indicating the presence bound water, plus a peak at 3560 cm1, indicating the presence of two crystallin AZI 27,28, while the polymer does not have a stretching vibrational peak in t Meanwhile, for AZIRL PO, the O stretching vibration peak 3560 cm1 di and only a broad absorption peak 3419 cm1, indicating the loss of AZI cry through the HME method as well as the formation of loosely bound water 27. Th probable hydrogen bond interaction among AZI and EudragitRL PO in strong ready by HME. Moreover, the stretching vibration peaks in the carbonyl group CO ar nificantly unique. AZI has a sharp and strong stretching vibration peak at 172 also includes a carbonyl stretching vibration peak at 1720 cm1. In AZIRL PO, the p quantity is 1734 cm1, the peak is blueshifted, and the peak intensity is lowered, a hydrogen bond break between the water of crystallization and AZI.Figure 12. PXRD spectrum AZIRL PO a PM b EudragitRL PO c AZI d.Figure 12. PXRD spectrum AZIRL PO a PM b EudragitRL PO c AZI d.three.3.3.