Failure to normalise the CIG by day 1 after admission to the HDU is an excellent marker for mortality and length of hospital stay, and should be used to guide resuscitation.P452 Allopregnanolone site Lactate levels from arterial, central venous and peripheral venous blood in severe Conduritol B epoxide MedChemExpress sepsis and septic shock patientsM Assuncao, A Nascente, C Guedes, B Mazza, M Jacki, H Fernandes, F Machado Universidade Federal de S Paulo, Brazil Critical Care 2007, 11(Suppl 2):P452 (doi: 10.1186/cc5612) Conclusion In critically ill patients with severe sepsis/septic shock a score based on age and increased GC376 Purity plasma levels of cardiac biomarkers can help risk-stratify Ilicicolin D Description 8612292" title=View Abstract(s)">GC376 Autophagy pubmed ID:https://www.ncbi.nlm.nih.gov/pubmed/8612292 patients and predict short-term (<6 months) outcome.Es were taken for five sequential days on all patients admitted with severe sepsis/septic shock. The mean hospital stay was Lanabecestat Inhibitor significantly GC376 Description longer in patients with a CIG > 10 mmol/l (46.6 vs 18.7 days, P = 0.015, t test) (Table 1).Table 1 (abstract P451) Day 1 CIG < 10 mmol/l Inhospital mortality Length of hospital stay 4.7 (n = 86) 18.7 days Day 1 CIG > 10 mmol/l 26.1 (n = 23) 46.6 days P value P = 0.006 (2 test) P = 0.015 (t test)Conclusion We describe the CIG for the first PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/16657964 time in the critically ill surgical patient, and quantify it using simple bedside calculations derived from routine blood investigations. A CIG > 10 mmol/l correlated very strongly with mortality. The mortality in patients with a CIG < 10 mmol/l (n = 86) was 4.7 . The mortality in patients with a CIG > 10 mmol/l (n = 23) was 26.1 (P = 0.006, chi-square test). There were no differences in CIG with respect to mortality on admission or day 2 (P = 0.273 and 0.104, respectively). The mean hospital stay was significantly longer in patients with a CIG > 10 mmol/l (46.6 vs 18.7 days, P = 0.015, t test) (Table 1).Table 1 (abstract P451) Day 1 CIG < 10 mmol/l Inhospital mortality Length of hospital stay 4.7 (n = 86) 18.7 days Day 1 CIG > 10 mmol/l 26.1 (n = 23) 46.6 days P value P = 0.006 (2 test) P = 0.015 (t test)Conclusion We describe the CIG for the first PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/16657964 time in the critically ill surgical patient, and quantify it using simple bedside calculations derived from routine blood investigations. Failure to normalise the CIG by day 1 after admission to the HDU is an excellent marker for mortality and length of hospital stay, and should be used to guide resuscitation.P452 Lactate levels from arterial, central venous and peripheral venous blood in severe sepsis and septic shock patientsM Assuncao, A Nascente, C Guedes, B Mazza, M Jacki, H Fernandes, F Machado Universidade Federal de S Paulo, Brazil Critical Care 2007, 11(Suppl 2):P452 (doi: 10.1186/cc5612) Conclusion In critically ill patients with severe sepsis/septic shock a score based on age and increased plasma levels of cardiac biomarkers can help risk-stratify PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/8612292 patients and predict short-term (<6 months) outcome.